MN1 and brain neoplasm: For example, brain tumor PT_E3ADF4ZB harbored oncogenic fusion MN1-PATZ1, where the DNA breakpoint resides in exon 1 of PATZ1 and disrupts the normal splicing acceptor (Supplementary Fig. 7a, where all four patients with MN1-PATZ1 in our cohort belong to neo-splicing category).