HLF and cancer: Indeed, RNA sequencing of CRISPR-edited HAL-01 cells confirmed a lack of alternative splicing (Supplementary Data 11) in TCF3 (when exon 16 is used) so that the host cancer cells are completely dependent on cryptic exons via neo-splicing, which is in clear contrast with the weak E14-4 alternative splicing in B-ALL with E15-4 version of TCF3-HLF (SJALL018389 in Supplementary Data 7 and 13).