Accordingly, C/EBPα-p42 or C/EBPα-p30 overexpression had no obvious effect on MOLM-13 and MV-4-11 cell growth in vitro (Figs. 2I and 5D) and less effect on MOLM-13 in vivo (Figs. 3D and 7C), but significantly exacerbated or impeded MV-4-11 AML progression in vivo (Supplementary Fig. 6A, B). The gene discussed is CEBPA; the disease is acute myeloid leukemia.