FLT3 and acute myeloid leukemia: To determine whether C/EBPα activation leads to FLT3i resistance, we infected FLT3-ITD AML cell lines (MV-4-11 and MOLM-13) with lentivirus carrying constitutively active C/EBPα-p42 (Fig. 2A) to generate respective stable cell lines and assessed the transcriptome of these C/EBPα-p42-overexpressing cells.