We previously demonstrated that administering a specific probiotics blend in a BxPC-3 xenografted mouse model of PDAC, treated or not with gemcitabine monotherapy, resulted in reduced stroma deposition and increased cell apoptosis within the tumor, preservation of the intestinal villi integrity, increased mucin production and proliferative activity of crypt epithelial cells, reduction of chemotherapy-related hematologic toxicity. The gene discussed is MUC5AC; the disease is neoplasm.