In PEG-B-COF + neutron-treated tumours, expression of pro-tumoural and immunosuppressive genes (Arg1, Ccl22, Lair1, Lgals3 and Mrc1) were downregulated, while pro-inflammatory chemokine genes (Xcl1 and Cxcl3), T/NK cell activation genes (Cd69, Stat4 and Cd2) and T/NK cell effector genes (Gzma, Gzmb, Ifng and Fasl) were upregulated (Figs. 5E and 5F). Here, STAT4 is linked to neoplasm.