CD4 and neoplasm: FACS analysis suggest that both PEG-B-COF + neutron-treated tumours and boron capsule+neutron-treated tumours, had increased populations of CD3 + , CD4 + and CD8 + (Fig. 5G-H, Supplementary Fig. 25A, Supplementary Table 11-12), and decreased populations of Treg cells (Fig. 5I) compared to other groups.