RHOA and COVID-19: RhoA/Rho-kinase signalling pathways control VSMC contraction, migration, and growth, and increased Rho-kinase activity is evident in models of vascular dysfunction.14,15 The potential antiviral effects of Rho-kinase inhibition as a treatment for acute COVID-19 have been postulated16–19; however, there are no reported data on Rho-kinase inhibition for the treatment of post-COVID-19 conditions.