CRP and cancer: Individuals with persistently low CRP levels had the lowest risk of developing cancer (IR, 7.7 per 1000 person-years), those that changed categories had an intermediate risk (IR, 12.2 and 11.9 per 1000 person-years in low-high and high-low categories, respectively), and those with persistently high CRP levels displayed the highest risk (IR, 14.0 per 1000 person-years) (Figure).