The etiology of PRPF8-linked RP comprises nearly two dozen heterozygous genetic variants (McKie et al, 2001; De Erkenez et al, 2002; Ruzickova & Stanek, 2017) with predominance of missense mutations clustering to very C-terminus of PRPF8 that is responsible for the SNRNP200 modulation (Mozaffari-Jovin et al, 2013). Here, PRPF8 is linked to retinitis pigmentosa 1.