Congenital mutations in genes encoding core spliceosome constituents including PRPF8 (McKie et al, 2001), SNRNP200 (Zhao et al, 2009), PRPF3 (Chakarova et al, 2002), PRPF4 (Chen et al, 2014), PRPF6 (Tanackovic et al, 2011a), and PRPF31 (Vithana et al, 2001) have been identified causative in a subset of familial blindness disorders known as non-syndromic retinitis pigmentosa (RP) (for a review, see Krausova & Stanek, 2018). Here, PRPF8 is linked to retinitis pigmentosa 1.