RP mutations in PRPF31 evoke mis-splicing of numerous retina-specific genes including rhodopsin and ciliary and cellular adhesion genes, which disrupt the structural organization of RPE and photoreceptors (Yuan et al, 2005; Mordes et al, 2007; Ray et al, 2010; Yin et al, 2011; Buskin et al, 2018). The gene discussed is PRPF31; the disease is retinitis pigmentosa 1.