A recent meta-analysis of 11 cohort studies suggested that an increment in sugar sweetened beverage consumption of 250 mL/day was associated with a 4% (hazard ratio 1.04, 1.02 to 1.06) higher risk of all cause mortality (low; III).76 Moreover, a harmful association between sugar sweetened beverage consumption and the risk of depression was observed in a meta-analysis of 10 observational studies (risk ratio 1.31, 1.24 to 1.39) (low; II).77 No significant association was observed between fructose intake and alanine transaminase concentration (low; NS) (fig 2; fig 6).78 This evidence concerns the gene GPT and major depressive disorder.