By performing immunostaining of T cells with the CD3 marker (72), B cells with the CD19 marker (73), NK cells with the CD56 marker (74), macrophages with the CD68 marker (75), and dendritic cells with the CD83 marker (76) in the OA and RA samples, we obtained consistent results that were calculated using the proteomics data and the publicly available immune cell gene sets (Fig. 6D). This evidence concerns the gene NCAM1 and rheumatoid arthritis.