CYP7A1 and obesity due to melanocortin 4 receptor deficiency: Notably, adenovirus-mediated reconstitution of CYP7A1 in these mice reduced hepatic-free cholesterol and oxidative stress and reversed hepatic inflammation and fibrosis, suggesting CYP7A1 plays a key role in maintaining cholesterol homeostasis and protecting against hepatic inflammation and injury, and diet-induced obesity and fatty liver disease.