CREB1 and cancer: Especially interesting was the prevalence of conserved binding sites of CREB in promoters of upregulated genes (45 motifs in 39 genes; Fig. 3E) because CREB-mediated transcription has been shown to be involved in Lnc473 autoregulation in cancer (19) and cAMP/CREB signaling has been proposed to be altered by ectopic cortical Lnc473 expression in female mice (17).