The compared with adjacent non-tumorous tissues, we found a higher level of RBM15, IGFBP1, RBMX, FTO, and ALKBH5 in all five STAD tissues, RBM15, FTO and ALKBH5 were overexpressed in STAD tumor tissues, while the expression of IGFBP1, RBMX was not changed in STAD tumor tissues. The gene discussed is ALKBH5; the disease is gastric adenocarcinoma.