In this context, our study has some limitations, such as we did not perform experiments to test HLA ligand genes, as well as the phenotype of NK cells was also not analysed, however in this study, the main focus was to evaluate the influence of the polymorphism KIR gene on the course of infection of OTR and its association with recurrences after an active episode. This evidence concerns the gene KIR3DL1 and infection.