PTEN and Familial prostate cancer: We further used GSEA to query gene sets generated from well-established prostate cancer GEM models, including sets of genes up-regulated and down-regulated of the Hi-MYC mouse compared to normal prostate (36), of the Pten-deleted mouse compared to normal prostate (25), and of ERG-positive versus ERG-negative prostate in the setting Pten deletion (9).