The protein dosage of PEA3 subfamily of ETS transcription factors ETV1, ETV4, and ETV5 is regulated through both transcription and ubiquitylation-mediated protein degradation by E3 ubiquitin ligase COP1, a tumor suppressor in both human prostate cancer and in GEM models of prostate cancer (22–24). The gene discussed is COP1; the disease is prostate cancer.