At 4 months after TAM administration, the percentage of Luminal_ETV4 cells in T2; ETV4AAA;Trp53LoxP/LoxP was significantly higher than that in T2; ETV4AAA mice, indicating that loss of p53 facilities the persistence of this neoplastic population and allowing for tumor progression over time (Fig. 5D). Here, TP53 is linked to neoplasm.