STAT6 and Granuloma: In histological staining of granuloma regions, Relm-α was abundantly expressed in IL-4c-treated Mac-STAT6 mice, more prominent than in the PBS or STAT6ko controls and co-staining with CD68 and DAPI confirmed Relm-α expression in AAMs with similar frequency in Mac-STAT6 and WT mice (Fig 2C).