HMGB1 and myeloid sarcoma: Regarding associations of these proteins related to the cells belong to in our study, it was shown that HMGB1 expression levels were increased in PBMCs of MS patients significantly (Malhotra et al. 2015, Paudel et al. 2019), and various VCAM1 positive microglia/macrophages exist at the edges of MS lesions (Peterson et al. 2002).