Barcellos et al. (2006) reported that there is a strong association between certain variants of HLA-DRB1 and MS in a comprehensive study that includes data from diverse populations. Farias et al. (2014) reported that ALDOA and APOE genes are up-regulated in CSF of MS patients. In addition, Guan et al. (2011) showed that CD44 controls the development of EAE. The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.