DHTs were shown to support patients in self-monitoring and self-managing diabetes, COVID-19 infection, medication adherence, cardiovascular disease, and general health, increasing patients’ involvement in their own health care [43,50,53,58,64,69]; for example, Vitale et al [53] developed a diabetes telemanagement system that was found to improve diabetes self-management in terms of frequency of blood glucose monitoring and frequency of insulin use. This evidence concerns the gene INS and cardiovascular disorder.