While a lot remains to be known regarding the mechanisms underlying cGAS-STING–mediated immunosurveillance of mitotic errors and their respective implications for tumor evolution, defective micronuclei are now well established as potential hubs for chromothripsis (Crasta et al., 2012; Hastings et al., 2009; Kneissig et al., 2019; Liu et al., 2011; Stephens et al., 2011; Zhang et al., 2015). Here, CGAS is linked to neoplasm.