While the high rates of aneuploidy during female meiosis have been linked to a weakened SAC and intrinsically unstable kinetochore–microtubule attachments (Kitajima et al., 2011; Kyogoku and Kitajima, 2017; Touati and Wassmann, 2016; Yoshida et al., 2015), aneuploid cancer cells are known to have a robust SAC (Rieder and Maiato, 2004; Tighe et al., 2001). Here, ADCY10 is linked to cancer.