The suggested inverse association between serum albumin level and Aβ levels in serum and brain tissue directly results in the impaired sink hypothesis and may act as the main triggering factor for liver injury, cardiac dysfunction, and AD progression as illustrated in Fig. 10 (Zuccalà et al. 2005a; Mizrahi et al. 2008; Llewellyn et al. 2010b). Here, ALB is linked to Alzheimer disease.