TNF and Alzheimer disease: The significant increase in Aβ serum level was displayed and found to be associated with a well-marked increase in TNF-α, IL-6, and caspase-3 release levels following the induction of neuroinflammatory AD type in group (II) when compared with the control group (I) (P < 0.05, n = 6) as shown in Fig. 4(a–c).