POU4F3 and breast cancer: UMAP embedding of SCENIC TF activity revealed four developmental branch endpoints derived from RPCs, which were demarcated and represented by respective TFs reported to affect the development of related lineages (Figure 2D), such as SOX8 for the MGC lineage, POU4F3 for RGC lineage, TFAP2B for HC/AC lineage, and LHX4 and NEUROD1 for BC/PH lineage.[21, 23, 24, 25]