APOE and age-related macular degeneration: Moreover, a degree of correlation was detected between most of these diseases and MGCs, particularly vascular eye diseases, which is consistent with the impact of MGCs on retinal angiogenesis under pathological conditions.[40] In particular, MGC2 was most closely related to the pathogenic genes of three diseases, namely DR, AMD, and retinopathy of prematurity (ROP), as evidenced by the highly specific expression of VEGFA, KDR, APOE, and AGER, revealing the active involvement of MGC2 subpopulations in vascular eye diseases (Figure 7I).