PRDM1 and VSX2—two antagonistic TFs involved in BC/PH lineage specification—are vital for the fate selection of photoreceptors and BCs in the final state, respectively.[37] Herein, we predicted that many TFs, besides OTX2 and CRX, were able modulate PRDM1 transcription, including THRB, RXRG, and RAX, which could maintain its expression in photoreceptor precursors and photoreceptors (Figure S9F, Supporting Information). Here, PRDM1 is linked to breast cancer.