Neutrophil accumulation in the tissue of ΔRD1-infected CCR2−/− mice reached a level similar to that in WT-infected CCR2-proficient animals (Fig. S8A) without leading to significantly increased disease (Fig. S8C), a finding that might reflect the lower bacterial burden in ΔRD1 infection (Fig. S8B) and/or the role for ESX-1-dependent phenotypic maturation of neutrophils (Fig. 5) for their ability to promote inflammation. The gene discussed is ESX1; the disease is infection.