After cerebral ischemia–reperfusion, the phosphorylation level of AMPK in the cerebral cortex decreases, resulting in a decrease in the expression of SIRT1, while 14, 15‐EET treatment increases the phosphorylation level of AMPK and upregulates the expression of SIRT1 as well as the phosphorylation of FoxO1 (Figure 7). This evidence concerns the gene FOXO1 and Cerebral ischemia.