OPA1 and Cerebral ischemia: This study showed that cerebral ischemia–reperfusion increased the expression of mitochondrial fission‐related protein Fis 1 and decreased expression of mitochondrial fusion‐related proteins MFN1, MFN2, and OPA1 in mice brain, resulting in mitochondrial dynamics disorder and structural damage, aggravating neuronal apoptosis and neurological impairment.