The DISC1 protein signaling pathway has been linked to multiple deficits in brain development both in humans and animals, which may lead to schizophrenia, bipolar disorder, recurrent major depression, and other neuropsychiatric disorders in humans, as well as phenotypical alterations reminiscent of human psychiatric disorders in animals (Austin et al., 2003; Clapcote et al., 2007; Hashimoto et al., 2006; Kirsty Millar et al., 2000; Shokouhifar et al., 2019). The gene discussed is DISC1; the disease is schizophrenia.