The first limitation prevented the comparison of proteomic differences between healthy individuals and AML patients However, six proteins (including GLUL, FH, LTF, ENO1, HADH, and IDH2) with relative high FC ratios between patients with poor-risk, favorable-risk, and intermediate-risk AMLs were identified as potent prognostic proteins in AML. The gene discussed is HADH; the disease is acute myeloid leukemia.