With the objective of evaluating the duration of pituitary desensitization after a single i.m. injection of 3.75 mg of triptorelin or leuprorelin, Matteo et al. (2006) recruited 60 women with stages I–II endometriosis and administered a depot preparation of each GnRH agonist on the 21st day of the cycle to 30 participants. The gene discussed is GNRH1; the disease is endometriosis.