Previous studies showed that IHC expression of p16, CDK4, and MDM2 in adipocytic tumors found that a combination of CDK4 and p16 had even better discriminatory power to differentiate well and dedifferentiated liposarcomas from lipoma and also found that p16 was the most sensitive and specific among the three markers [15,20]. This evidence concerns the gene CDK4 and liposarcoma.