The IHC expression of p16, CDK4, and combined (p16+CDK4) markers in various lineages of soft tissue tumors are shown in Table 5. Positive p16 expression was observed in 36 cases (51.4%) while negative p16 expression was observed in 31 cases (44.3%) and the remaining three cases were found to be focal positive (4.3%). This evidence concerns the gene CDK4 and soft tissue neoplasm.