APOE and Alzheimer disease: In addition, we performed secondary analyses between Aβ-positive (representing Alzheimer’s pathological change or preclinical AD [35]) and Aβ-negative individuals and investigated the association between imaging and fluid biomarkers of neuroinflammation and Aβ deposition and markers of disease progression (cognitive performance and volumetric brain changes) in our cohort comprised by cognitively unimpaired participants enriched with APOE ε4 carriers.