IRS1 and cancer: Several other notable genes shared by at least two lines have been previously implicated in cancer, including Epidermal Growth Factor Receptor Kinase Substrate 8 (EPS8) which has been associated with poor prognosis in ALL and is known to regulate proliferation and apoptosis [22], FAM92A (also known as BARMR1) which has been negatively correlated with prognosis in AML and shown to promote proliferation and colony formation [23], and insulin receptor substrate 1 (IRS1) which can activate PI3K/AKT/mTOR, B-catenin, and MAPK has been a target for inhibiting MAPK in ALL [24, 25].