Meanwhile, screening of epigenetic inhibitor library and herbal small molecule compound library using 3D in vitro model revealed that GSK-LSD1, CUDC-101, BML-210 and ATT-1 could increase the expression of MHC-I on tumor cell and promote tumor antigen presentation respectively, and the combination with PD-1 antibody could enhance the killing toxicity of CD8+ T cells [74, 75]. Here, CD8A is linked to neoplasm.