Finally, to provide animal model validation and assess the extent to which hTau.P301S and/or rTg4510 mice accurately recapitulate AD versus familial FTD, as well as to elucidate differences in the tau PTM profile between these different forms of tauopathy, Wenger and colleagues examined tau PTMs in human FTD patients carrying the MAPT P301L mutation (FTD/P301L). Here, MAPT is linked to frontotemporal dementia.