JUN and malignant colon neoplasm: It has been demonstrated that phosphorylation of H3 at the S10 site by TOPK promotes proliferation of breast cancer [34], phosphorylation of PRPK at the S250 site by TOPK promotes metastasis of colon cancer [35], and phosphorylation of c-Jun at the S63/73 site promotes the development of drug resistance in lung cancer [36].