Next, we used migration and invasion assays to verify whether the pro-metastatic ability of FYN-induced GC cells was mediated by TOPK, and the results showed that the metastatic ability of cells in the OE-FYN group was significantly enhanced compared with the PCMV group, while the addition of TOPK inhibitor OTS514 reversed this phenomenon (Fig. 5E). Here, FYN is linked to gastric cancer.