RIPKs family includes seven members with serine/threonine activity and closely participate in the initiation and progression of digestive malignancies, among which RIPK1, RIPK3 and RIPK4 have been studied on their promotive role in PC oncogenesis, apoptosis and necroptosis (Zhang et al. 2021a). Here, RIPK3 is linked to pachyonychia congenita.