The oncogenic role of PRKCI-encoding protein PKC iota has been well established, recent studies in PC suggested that mutated KRAS can elevate and activate PKC iota to disable growth-inhibitory Hippo signaling and promote Yes-associated protein1 (YAP-1) translocation into nucleus, and thus maintain PC cells growth (Wang et al. 2020). Here, PRKCI is linked to pachyonychia congenita.