KEGG analysis indicates these DEGs were mainly involved in pathways in cancer, PI3K-Akt signaling pathway, proteoglycans in cancer, focal adhesion, ECM-receptor interaction, glycine, serine and threonine metabolism, etc. (p < 0.05, Fig. 1F) These results suggest an intimate relationship between DEGs and malignant PC behavior. Here, AKT1 is linked to pachyonychia congenita.