A total of 7 genes out of 215 DTU genes in 12-month-old Trem2*R47H male mice overlapped (hypergeometric p = 0.004) with differentially spliced genes in human asymptomatic AD cases compared to controls (PPP1R9B, TMED4, HYOU1, NT5DC1, PFN2, CCDC91, and PSMD2), symptomatic AD cases compared to controls (EIF5B, HNRNPM, CDK5, NPEPPS, KIF3A, MRPS7, and CANX), and symptomatic AD cases compared to asymptomatic AD cases (YWHAE, SPTBN1, CDK5, MGLL, NT5DC1, PFN2, and MAGI2) [1] (Table 6). Here, TMED4 is linked to Alzheimer disease.