We found that 10 DEU genes (ENO2, KIF21A, ATL3, GLS, STXBP1, PPP3CA, MACF1, MAP1B, DPP6, and SMS) in 12-month-old Trem2*R47H mice overlapped with differentially spliced genes identified in human AD cases compared to AsymAD cases (hypergeometric p = 0.005) (Table 3). The gene discussed is SMS; the disease is Alzheimer disease.