Similarly, 5 genes (EFTUD2, DNM1L, STXBP1, DPP6, and SMS) with DEU in 12-month-old Trem2*R47H mice overlapped (hypergeometric p = 0.2) with differentially spliced genes in human AD cases compared to controls; and 6 genes (EFTUD2, KIF21A, DNM1L, MACF1, IST1, and PPP1R9B) with DEU in 12 months old Trem2*R47H mice overlapped (hypergeometric p = 0.02) with differential spliced gene sets in human asymptomatic AD cases compared to controls (Table 3). Here, MACF1 is linked to Alzheimer disease.