We noted that the OS of breast cancer patients was also affected by age (1.03485369, P = 7.23E-06), tumor stage (HR = 2.28016073, P = 2.95E-11), stage T (HR = 1.58856729, P = 4.54E-05), stage N (HR = 1.69043662, P = 5.01E-08), stage M (HR = 6.86369543, P = 8.21E-11), and estrogen receptor (ER, HR = 0.62096529, P = 0.01822903). The gene discussed is ESR1; the disease is breast carcinoma.