Similarly, abnormally expressed serum levels of S100A4, S100A8, S100A9, CA-I, and annexin V proteins were found to serve to be effective protein biomarkers for BC diagnosis based on the analysis of 160 serum samples from 52 healthy individuals, 55 presurgical, and 53 postsurgical patients with BC [201]. Here, S100A8 is linked to breast cancer.