While the secretome produced by recombinant P2Y11 in human astrocytoma cells (1321N1) comprises IL-6 and IL-8 as well as sTNFR1, the secretome generated by the native P2Y11 in primary human (M2) macrophages lacks IL-6 but contains the pro-angiogenic factors IL-8 and VEGF as well as sTNFR2 (instead of sTNFR1). This evidence concerns the gene P2RY11 and astrocytoma (excluding glioblastoma).