By applying orthopedic criteria to analyze spine misalignments in pkd2l1 mutants, including the amplitude and location of hyper-kyphosis in the thoracic spine, curve pattern, sagittal balance, and sex bias, we further confirm that the loss of the mechanosensory function of CSF-cNs in pkd2l1 mutants is associated with a deformity reminiscent of Scheuermann’s disease. This evidence concerns the gene PKD2L1 and Scheuermann disease.