Thus, we randomized mice bearing either a poorly responsive small (~ 100 mm3) B78 tumor or two large (~ 350 mm3 per tumor) A20 tumors into 4 treatment groups: PBS, anti-CTLA-4, CpG + OX40, and CpG + OX40 + anti-CTLA-4. Here, CTLA4 is linked to neoplasm.