Our data suggest that more time in the host allows for more tumor growth and more immunoediting (potentially of the tumor cells or of the tumor microenvironment), and thus leads to more difficult to treat tumors (e.g. decreased MHC-I, MHC-II, and CD80/86 expression in large A20 tumors shown here) (Fig. 3a–c). Here, CD80 is linked to neoplasm.