In the MSS-CRC and PDAC expansion cohorts, 4 of 6 patients with matched biopsies had an increase in CD8+ T cell infiltration in tumors along with increased PD-L1 expression and granzyme B positive cells, further reinforcing the immunomodulatory effect of this combination in tumor types that are generally considered immune quiescent. Here, CD8A is linked to colorectal carcinoma.