Multiple tumor types express high levels of CD73 and adopt this system for evasion of immune surveillance [3, 4], including colorectal cancer (CRC) [5], pancreatic ductal adenocarcinoma (PDAC) [5, 6], and lung adenocarcinoma [7], notably epidermal growth factor receptor-mutant (EGFRm) adenocarcinoma [8, 9], with upregulation of CD73 increasing extracellular adenosine production resulting in local immunosuppression [3, 10]. Here, EGFR is linked to colorectal cancer.