TP53 and neoplasm: Consequently, the antitumor effects of PSO nano-emulsion observed in this study can also be attributed to the simultaneous dose-dependent upregulation of the expression levels of p53 and Bax apoptotic genes and the reduction in the expression level of the anti-apoptotic Bcl2 gene noticed in tumor tissues of mice treated with PSO nano-emulsions because overexpression of the tumor suppressor P53 and Bax genes stimulates apoptosis52.