Treatment with 100, 200, or 400 mg/kg body weight of PSO nano-emulsion (G4, G5, and G6 groups, respectively) resulted in a significant increase in the expression levels of p53 and Bax genes and a significant reduction in the expression level of Bcl2 gene compared to their expression levels in tumor tissues of tumor control (G2) group (Fig. 8). The gene discussed is TP53; the disease is neoplasm.