TP53 and neoplasm: Based on the data discussed above, treatment with tested doses of PSO nano-emulsions (100, 200 and 400 mg/kg) significantly reduced tumor volume and weight, in a dose dependent manner and induced DNA breaks that stimulates apoptosis of tumor cells by increasing the apoptotic p53, Bax and Caspase genes expression and decreasing the anti-apoptotic gene Bcl2 expressions.