However, by giving the different doses of PSO nano-emulsion, the expression levels of p53 and Bax genes were substantially declined compared to doxorubicin group expression levels; whereas the expression level of Bcl2 gene revealed a significant decline in the G4 group treated with 100 mg/kg of PSO nano-emulsion, but marked elevation was observed in the tumor tissue of mice given 200 mg/kg of PSO nano-emulsion (G5 group) as compared to their expression levels in doxorubicin treated mice (Fig. 8). Here, TP53 is linked to neoplasm.