We tested the hypothesis that activation of EPO/EPOR signaling in the condition of maternal HDP, a cause of UPI and infant IUGR, was vasoprotective under high oxygen by studying homozygous hWtEPOR and littermate control mWtEpoR pups in a combined maternal UPI-induced pup IUGR and OIR model (Fig. 1). Here, EPO is linked to fetal growth restriction.