PLOD1 and Hyperglycemia: There were also small but significant increases in carbonylated protein levels in STZ-diabetic mice that had not been exposed to hypoglycaemia (Fig. 2d; WT-EE vs STZ-HH, p<0.05), as well as non-diabetic mice who were exposed to post-hypoglycaemic hyperglycaemia (Fig. 2e; WT-LH vs WT-EE, p<0.05).