GCG and type 1 diabetes mellitus: In groups B and C, hypoglycaemia from a euglycaemic baseline resulted in significantly elevated glucagon and adrenaline plasma levels compared with group A. In contrast, in the STZ-diabetic mice (groups E and F), consistent with human type 1 diabetes, the glucagon response to a hypoglycaemic challenge was impaired (Table 1) [29] and the adrenaline response was severely blunted.