Transcript levels of Nqo1 and Sod2 were significantly elevated in STZ-diabetic mice following acute hypoglycaemia (STZ-LH vs WT-EE; p<0.05 for both genes), and the levels of Sod2 were further increased (>fivefold) in chronic hyperglycaemia. This evidence concerns the gene NQO1 and Hyperglycemia.