For example, the HSP90 protein that is a molecular chaperone and maintains protein homeostasis during cellular stress has been reported to facilitate infection of SARS-CoV-226, and help protein aggregation and toxic aggregate accumulation in neurodegenerative diseases27; the ALDH2 that is crucial in the oxidative metabolism of toxic aldehydes in the brain has been reported to be associated with neurodegenerative diseases28 and attenuated immune system to SARS-CoV-2 vaccination29. The gene discussed is HSP90AA1; the disease is infection.