We observed a significant increase in all BMP isoforms measured for LRRK2 G2019S mutation carriers irrespective of PD status but did not see a significant difference between PD manifesting compared to non-manifesting LRRK2 G2019S carriers which may be due to the relatively small group size (11 PD/7 NMC). The gene discussed is LRRK2; the disease is Parkinson disease.