On the other hand, YTHDF1 is upregulated by hypoxia-inducible factor-1α (HIF-1α) in HCC, thus promoting the formation of autophagosomes by enhancing the translation of a series of autophagy-related genes such as ATG2A and ATG14 [104], a role which has been confirmed by YTHDF1 conditional knockout transgenic mice. Here, YTHDF1 is linked to hepatocellular carcinoma.