In both human and mouse HCC, loss of YTHDF2 disrupts m6A-dependent mRNA decay of inflammation and angiogenesis-related mRNAs including IL-11 and SERPINE2 and the resulting increase in of IL-11 and SERPINE2 expression reshapes the HCC microenvironment by promoting inflammation and vascular remodeling [111]. The gene discussed is YTHDF2; the disease is hepatocellular carcinoma.