Also in the CRC, by utilizing the AOM/DSS combined YTHDF1 transgenic mice model, YTHDF1 was shown to promote tumorigenesis and metastasis through targeting m6A-ARHGEF2, which activates RhoA signaling and promotes the induction of stress fibers and focal adhesions [116]. This evidence concerns the gene YTHDF1 and colorectal carcinoma.