Knockout of METTL3 in tumor-infiltrating myeloid cells (TIMs) including tumor-associated macrophages (TAM), tumor-associated neutrophiles (TAN), and MDSCs disrupts the immunosuppressive functions of myeloid cells in the CRC model, which is mediated by a METTL3-JAL1-STAT3 signal cascade [140]. The gene discussed is STAT3; the disease is neoplasm.