Loss of ALKBH5 enhances the m6A modification on the 3’ UTR region of PD-L1 mRNA to promote its degradation in a YTHDF2-dependent manner, thus decreasing the expression of PD-L1 on monocyte/macrophage cells and increasing the infiltration of MDSC-like cells in intrahepatic cholangiocarcinoma (ICC). This evidence concerns the gene CD274 and intrahepatic cholangiocarcinoma.