PTEN and pancreatic ductal adenocarcinoma: In Hepatocellular Carcinoma (HCC), In PTEN-deficient pancreatic ductal adenocarcinoma (PDAC), aberrant MTC and YTHDF2 regulation increases PIK3CB mRNA stability through reducing m6A levels, which facilitates PTEN-deficient PDAC cell proliferation both in vitro and in vivo via the activation of AKT signaling pathway [93].