To determine how NR2F2-Iso2 enhances metastatic melanoma progression, we first profiled our LOF models with RNA-seq, identified genes that were differentially expressed between shNR2F2-Iso2 and shSCR expressing cells (p < 0.05) and ranked them from their highest to lowest fold-change expression for gene set enrichment analyses (GSEA) with the Hallmark reference gene sets. This evidence concerns the gene NR2F2 and melanoma.