To probe deeper into NR2F2-Iso2 regulated genes in melanoma, we identified NR2F2-Iso2 signature genes that were consistently down-regulated in shNR2F2-Iso2 compared to shSCR in 4L and 12-273BM cells (Fig. 4b; Supplementary Data 1). This evidence concerns the gene NR2F2 and melanoma.