NR2F2 and melanoma: This finding suggests that the pro-metastatic activity of NR2F2-Iso2 is dependent on its ability to dimerize with NR2F2-Iso1 and the formation of NR2F2-Iso1/NR2F2-Iso2 heterodimers during melanoma progression may alter interactions with other nuclear receptors, transcription factors or chromatin modifiers, resulting in the expression of metastasis promoting genes in melanoma cells (Supplementary Fig. 13).