NR2F2 and melanoma: Furthermore, NR2F2-Iso2 CpGs were more frequently hypomethylated (i.e., mean β value < 0.33) in metastatic (191 of 364; 52.5%) compared to primary (32 of 109; 29.4%) melanoma samples (p < 0.0001; Fig. 1g, h), while NR2F2-Iso1 CpGs were consistently hypomethylated in both, primary and metastatic samples (Supplementary Fig. 3b, c).