MLD-STZ models induce the activation of cell apoptotic pathways and autoimmune-mediated failure of pancreatic β cells functions, which lead to progressive hyperglycemia and severely impaired glucose tolerance in WT mice.24–26 Firstly, we examined oral bioavailability and pharmacokinetic characterization of IHMT-MST1-39 is studies in different species (Supplementary Table S1a) and found that this compound is distributed in multiple organs with especially high accumulation in the liver and pancreas (Supplementary Table S1b). Here, MST1 is linked to Hyperglycemia.