MST1 and Impaired glucose tolerance: MLD-STZ models induce the activation of cell apoptotic pathways and autoimmune-mediated failure of pancreatic β cells functions, which lead to progressive hyperglycemia and severely impaired glucose tolerance in WT mice.24–26 Firstly, we examined oral bioavailability and pharmacokinetic characterization of IHMT-MST1-39 is studies in different species (Supplementary Table S1a) and found that this compound is distributed in multiple organs with especially high accumulation in the liver and pancreas (Supplementary Table S1b).