MST1 and type 2 diabetes mellitus: MST1 is constitutively activated in the pancreatic islets of genetically defective diabetic mice, such as diabetic Leprdb mice (db/db mice).10 To evaluate whether MST1 inhibition by IHMT-MST1-39 can manage hyperglycemia in T2D mouse model in vivo, obese db/db mice were treated daily with IHMT-MST1-39 or vehicle for 10 weeks.