HMGCR and type 2 diabetes mellitus: Concordant with previous findings, MR analysis showed that reduced HMGCR expression in blood was associated with reduced LDL-C [4], reduced CAD risk [41], increased BMI [42] and nominally associated with increased T2D [43] (Fig. 3 and Additional File 6), demonstrating the suitability of this approach for investigating the effects of HMGCR inhibition.