CXCL5 is one of the binding ligands of CXCR2 [25], which enhances the migration of RCC cells and promotes epithelial-to-mesenchymal transition (EMT), which is blocked by the CXCR2 inhibitor SB225002 (Fig. 5E, F). This evidence concerns the gene CXCR2 and renal cell carcinoma.