L1CAM and uterine cancer: The disintegrin and metalloprotease (ADAM) family cleaves the transmembrane ectodomain of L1CAM extracellularly, releasing a soluble L1CAM ectodomain (L1CAM-ECD) of ~200 kDa from the cell surface, which has been detected in serum samples from patients with ovarian and uterine cancers [21, 22].