Multivariate analysis showed seven factors were independent risk factors for OS: baseline CAR > 0.51 (HR = 1.615, p = 0.001), NLR > 1.28 (HR = 1.705, p = 0.004), AGR < 1.36 (HR = 1.337, p = 0.018), NSE > 16.3 ng/mL (HR = 1.656, p = 0.004), hyponatremia (HR = 1.544, p = 0.003), SD + PD for the best efficacy to first‐line chemotherapy (HR = 1.641, p < 0.001), and extensive stage (HR = 1.731, p < 0.001). This evidence concerns the gene ENO2 and Hyponatremia.